1,9-Pentadecadiene-4,6-diyne-3,8-diol, (3S,8R,9Z)-

Name	Araliadiol
Synonyms	Araliadiol (3S,8R,9Z)-1,9-Pentadecadiene-4,6-diyne-3,8-diol 1,9-Pentadecadiene-4,6-diyne-3,8-diol, (3S,8R,9Z)-
CAS	1354638-93-9

biological activity	Araliadiol is a polyalkyne isolated from leaves of Aralia cordata Thunb. Araliadiol inhibited cell growth by MCF-7 with an IC50 value of 6.41 µg/mL.
Target	IC50: 6.41 µg/mL (MCF-7 cells growth)
Cell Line:	MCF-7 cells MCF-7 cells
Concentration:	20 µM, 40 µM, and 80 µM 20 µM, 40 µM, and 80 µM
Incubation Time:	0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours 48 hours
Result:	The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %). Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D 3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1).

Last Update：2024-04-09 21:04:16

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CAS: 1354638-93-9
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